Serum interleukin 18 and interleukin 18 binding protein in rheumatoid arthritis
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چکیده
منابع مشابه
Serum interleukin 18 and interleukin 18 binding protein in rheumatoid arthritis.
OBJECTIVE To measure serum interleukin 18 (IL18) and IL18 binding protein (IL18BP) levels in patients with inflammatory arthropathies, and to identify associations with disease status and the response to treatment. METHODS Serum samples were obtained before and after methotrexate treatment from patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA) attending an early arthritis ...
متن کاملInterleukin-18 and IL-18 Binding Protein
Interleukin-18 (IL-18) is a member of the IL-1 family of cytokines. Similar to IL-1β, IL-18 is synthesized as an inactive precursor requiring processing by caspase-1 into an active cytokine but unlike IL-1β, the IL-18 precursor is constitutively present in nearly all cells in healthy humans and animals. The activity of IL-18 is balanced by the presence of a high affinity, naturally occurring IL...
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These include: References http://ard.bmjjournals.com/cgi/content/full/62/suppl_2/ii48#BIBL This article cites 19 articles, 14 of which can be accessed free at: Rapid responses http://ard.bmjjournals.com/cgi/eletter-submit/62/suppl_2/ii48 You can respond to this article at: service Email alerting top right corner of the article Receive free email alerts when new articles cite this article sign u...
متن کاملTargeting interleukin 18 with interleukin 18 binding protein.
A novel, constitutively expressed and secreted interleukin 18 (IL18) binding protein (IL18BP) neutralises IL18. IL18BP shares many characteristics with soluble cytokine receptors of the IL1 family in that the protein exhibits specificity for IL18, belongs to the immunoglobulin-like class of receptors and has limited amino acid sequences with those of the IL1 receptor type II. However, unlike so...
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To evaluate the balance status of interleukin 18 (IL-18) and interleukin 18 binding protein (IL-18BP) in circulation in patients with lupus nephritis (LN) and primary nephrotic syndrome (PNS), plasma levels as well as mRNA expression in peripheral blood mononuclear cells (PBMCs) of IL-18 and IL-18BP were measured by ELISA and RT-PCR respectively. The ratio of IL-18/IL-18BP was also calculated. ...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2002
ISSN: 0003-4967
DOI: 10.1136/ard.61.8.726